Snup Stada Overdosage

Symptoms of intoxication: The clinical picture of intoxication with imidazole derivatives may be confusing, because phases of stimulation may alternate with phases of suppression of the central nervous system and of the cardiovascular system.
Symptoms of central nervous system stimulation are anxiety, agitation, hallucinations and convulsions.
Symptoms following inhibition of the central nervous system are lowering of body temperature, lethargy, somnolence and coma.
The following symptoms may also occur: Miosis, mydriasis, perspiration, fever, paleness, cyanosis, nausea and vomiting, tachycardia, bradycardia, cardiac arrhythmias, cardiac arrest, palpitation, hypertension, shock-like hypotension, pulmonary edema, respiratory depression and apnea, psychogenic disorders.
Following overdosing dominating central nervous effects with seizures and coma, bradycardia, apnea as well as hypertension replaced by hypotension are common especially in children.
Therapy of intoxication: After severe overdosing intensive care treatment in a hospital is indicated. Administration of activated charcoal (absorbent), sodium sulfate (laxative) or gastric lavage (after large amounts) should be initiated immediately, because absorption of xylometazoline may be quick. For blood pressure reduction a non-selective alpha blocker may be given.
Vasopressors are contraindicated. Antipyretic, anticonvulsant therapy and oxygen if necessary.